Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex

Peer reviewedPublisher PD

Jadeite originating from plagioclase in L6 and H6 chondrites

第2回極域科学シンポジウム/第34回南極隕石シンポジウム 11月18日（金） 国立国語研究所 2階講

Discovery of Strong Radiative Recombination Continua from The Supernova Remnant IC 443 with Suzaku

We present the Suzaku spectroscopic study of the Galactic middle-aged supernova remnant (SNR) IC 443. The X-ray spectrum in the 1.75-6.0 keV band is described by an optically-thin thermal plasma with the electron temperature of 0.6 keV and several additional Lyman lines. We robustly detect, for the first time, strong radiative recombination continua (RRC) of H-like Si and S around at 2.7 and 3.5 keV. The ionization temperatures of Si and S determined from the intensity ratios of the RRC to He-like K-alpha line are 1.0 keV and 1.2 keV, respectively. We thus find firm evidence for an extremely-overionized (recombining) plasma. As the origin of the overionization, a thermal conduction scenario argued in previous work is not favored in our new results. We propose that the highly-ionized gas were made at the initial phase of the SNR evolution in dense regions around a massive progenitor, and the low electron temperature is due to a rapid cooling by an adiabatic expansion.Comment: 5 pages, 5 figures, accepted by ApJ Lette

Constitution of the Indium-Rich Portion of the Indium-Magnesium System

The equilibrium phase diagram of the indium-magnesium system in the range up to 40 at.% Mg has been established by X-ray diffraction and thermal analysis. The solid-solubility of magnesium in indium does not exceed about 5 at.%. An intermediate solid solution, γ, with a face-centered cubic structure exists over a wide range of composition. An ordered phase, γ\u27, with superstructure of Cu_3Au-type, is formed near 28 at.% Mg at temperatures below 114℃. The axial ratio c/a of the primary solid solution of indium in magnesium changes as a function of electron/atom ratio as in the parallel case of the indium-cadmium system. Reasons are advanced to explain the conflict between the present results and those of earlier investigators

Enhanced bone-forming activity of side population cells in the periodontal ligament.

Regeneration of alveolar bone is critical for the successful treatment of periodontal diseases. The periodontal ligament (PDL) has been widely investigated as a source of cells for the regeneration of periodontal tissues. In the present study where we attempted to develop an effective strategy for alveolar bone regeneration, we examined the osteogenic potential of side population (SP) cells, a stem cell-containing population that has been shown to be highly abundant in several kinds of tissues, in PDL cells. Isolated SP cells from the rat PDL exhibited a superior ability to differentiate into osteoblastic cells compared with non-SP (NSP) and unsorted PDL cells in vitro. The mRNA expressions of osteoblast markers and bone morphogenetic protein (BMP) 2 were significantly upregulated in SP cells and were further increased by osteogenic induction. To examine the boneforming activity of SP cells in vivo, PDL SP cells isolated from green fluorescent protein (GFP)-transgenic rats were transplanted with hydroxyapatite (HA) disks into wild-type animals. SP cells exhibited a high ability to induce the mineralized matrix compared with NSP and unsorted PDL cells. At 12 weeks after the implantation, some of the pores in the HA disks with SP cells were filled with mineralized matrices, which were positive for bone matrix proteins, such as osteopontin, bone sialoprotein, and osteocalcin. Furthermore, osteoblast- and osteocyte-like cells on and in the bone-like mineralized matrices were GFP positive, suggesting that the matrices were directly formed by the transplanted cells. These results suggest that PDL SP cells possess enhanced osteogenic potential and could be a potential source for cell-based regenerative therapy for alveolar bone

Budding yeast Rif1 binds to replication origins and protects DNA at blocked replication forks

We thank Javier Garzon and Vamsi Krishna Gali for discussion and advice on methods, and Takashi Kubota for helpful comments on the manuscript. This work was supported by Cancer Research UK Programme Award A19059 to ADD and SH. KS was supported by Grant‐in‐Aid for Scientific Research on Priority Areas (15H05970 and 15K21761) from Ministry of Education, Culture, Sports, Science and Technology, Japan. Funding Cancer Research UK (CRUK) A19059 Ministry of Education, Culture, Sports, Science and Technology (MEXT) 15H0597015K21761 Data availability ChIP‐Seq data and corresponding input data were submitted to ArrayExpress under accession number E‐MTAB‐6736.Peer reviewedPublisher PD

High-Energy Neutrino Astronomy

Kilometer-scale neutrino detectors such as IceCube are discovery instruments covering nuclear and particle physics, cosmology and astronomy. Examples of their multidisciplinary missions include the search for the particle nature of dark matter and for additional small dimensions of space. In the end, their conceptual design is very much anchored to the observational fact that Nature accelerates protons and photons to energies in excess of $10^{20}$ and $10^{13}$ eV, respectively. The cosmic ray connection sets the scale of cosmic neutrino fluxes. In this context, we discuss the first results of the completed AMANDA detector and the reach of its extension, IceCube. Similar experiments are under construction in the Mediterranean. Neutrino astronomy is also expanding in new directions with efforts to detect air showers, acoustic and radio signals initiated by super-EeV neutrinos.Comment: 9 pages, Latex2e, uses ws-procs975x65standard.sty (included), 4 postscript figures. To appear in Proceedings of Thinking, Observing, and Mining the Universe, Sorrento, Italy, September 200